Sistema de Información de Ciencia y Tecnología

Biomoleculas De Interes Medicinal E Industrial Anticancerigeno

Nombre Abreviado 386 ANTICANCER
Financiamiento ASDI
Convocatoria Programa UMSA - ASDI 2013 - 2017
Categoria y Convocatoria del proyecto Programa UMSA - ASDI
Duración Inicio: 01/01/2014 Fin: 01/12/2014
Tipo de Investigación
Datos SIGEP:
Unidad ejecutora	Programa	Sub-programa	Proyecto	Actividad
95	51	0	0000	386
Resumen del Proyecto
Bolivia has a fantastic endemic flora with up to 6,000 vegetal species per 10,000 km², classified as one of the most important in the world. This is a unique natural resource that is possible for Bolivia to exploit. Natural products produced by plants and other organisms continue to play a crucial role in the discovery of new drugs, several reports showed the importance to combine natural products with modern techniques to discover new lead molecules for the prevention or treatment of several maladies. In this way, this project will investigate the potential of Bolivian natural products to be used in the treatment of cancer and other related non-transmissible maladies.
The project will be performed in a team consisting of chemists and biologists who work in collaboration with specialist medical doctors when it is needed. The project includes the isolation, identification, analytical control, modelling, derivatization and biological evaluations of molecules from natural sources with anti-inflammatory and/or anti-cancer activities. Chemical studies of natural products and derivatives will be done in collaboration with LU-CAS...Ver mas
Bolivia has a fantastic endemic flora with up to 6,000 vegetal species per 10,000 km², classified as one of the most important in the world. This is a unique natural resource that is possible for Bolivia to exploit. Natural products produced by plants and other organisms continue to play a crucial role in the discovery of new drugs, several reports showed the importance to combine natural products with modern techniques to discover new lead molecules for the prevention or treatment of several maladies. In this way, this project will investigate the potential of Bolivian natural products to be used in the treatment of cancer and other related non-transmissible maladies.
The project will be performed in a team consisting of chemists and biologists who work in collaboration with specialist medical doctors when it is needed. The project includes the isolation, identification, analytical control, modelling, derivatization and biological evaluations of molecules from natural sources with anti-inflammatory and/or anti-cancer activities. Chemical studies of natural products and derivatives will be done in collaboration with LU-CAS and UMSA-IIQ, while biological studies will be performed in collaboration with LU-CPG and UMSA-IBMB. Based on those collaborations, the plan is to strengthen the emergent line of medicinal chemistry at IIQ and anti-cancer line at IBMB through the training of personal highly qualified to develop chemical and biological studies of Bolivian natural products to find new anti-cancer, anti-genotoxic and/or anti-inflammatory lead compounds. In relation to cancer, we will initiate the studies with breast cancer as the main cancer group as there is large experimental and theoretical knowledge around this cancer form at LU. In addition other cancer forms such as prostate and pancreatic cancer will be included to investigate the generalization of similarities in metastatic cancer. In addition, all pure molecules isolated or synthesized will pass to IIFB for anti-parasitic evaluations in order to determine potential anti-parasitic biomolecules.
Results of the scientific findings, based on traditional knowledge, will be returned to the communities for a better local use of the medicinal species, but also they would be used to develop novel products with a commercial potential to support novel industry in Bolivia. In addition, the current program foresees to implement a PhD program at UMSA, based on the existing Master Degree programs where IIFB, IIQ and IBMB participate.
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Objetivos

Objetivo General

• To optimize the use of human and financial resources for research at IIFB, IIQ and IBMB, training scientists working in multidisciplinary projects, establishing mechanisms to use the big equipments and articulating the existing M.Sc. programs where participate IIFB, IIQ and IBMB and implementing a multidisciplinary PhD program at UMSA in the area

• To increase the ideal personal, highly qualified and recognized, to develop chemical and biological research on Bolivian plants, used in local traditional medicines, in order to generate knowledge for a better understanding of their potential for health purposes (inflammations and cancer)

• To increase the effective use of research results, returning the results of medicinal plants to the communities for a better local use and transferring some results to Bolivian Pharmaceutical Industry to develop novel products with commercial potential

Objetivos Especificos

• To increase the ideal personal, highly qualified and recognized, to develop chemical and biological research on Bolivian plants, completing the PhD studies of candidates of the project Research on Plant Biodiversity and initiating the studies of New PhD and MSc candidates of the project Anticancer Biomolecules

• To optimize the use of human and financial resources for research at IIFB, IIQ and IBMB, training scientists working in multidisciplinary projects, establishing mechanisms to use the big equipments and starting the articulation of the existing M.Sc. programs where participate IIFB, IIQ and IBMB

• To increase the effective use of research results, returning the results of plants to the communities for a better local use and transferring some results to Bolivian Pharmaceutical Industry to develop novel products with commercial potential

Participantes

Coordinador Giovanna Rocio Almanza Vega

Co-cordinador Gloria del Carmen Rodrigo Lira


- Participantes del proyecto

Nombre	Grado Académico	Cargo	Cédula de identidad
Abel Franz Gutierrez Escalera	Licenciatura	Apoyo administrativo (Categoria D)
Erick Castillo Laura	Licenciatura	Apoyo administrativo (Categoria D)
Silvia Eugenia Ramos Paredes	Licenciatura	Becario PostGrado (Categoria D)
Santos León Quispe Achu	Licenciatura	Becario PostGrado (Categoria D)
Sergio Daniel Torrez Alvarez	Licenciatura	Becario PostGrado (Categoria D)
Christian Eduardo Carrasco Machicao	Licenciatura	Becario PostGrado (Categoria D)
Marcos Heriberto Quiroz Mendoza	Licenciatura	Becario PostGrado (Categoria D)
Brigida Maribel Mamani Acomata	Universitario	Becario Pregrado (Categoria D)
Aleyda Huayhua Llusco	Licenciatura	Becario Pregrado (Categoria D)
Victor Hugo Carballo Mamani	Bachiller	Becario Pregrado (Categoria D)
Franz Hugo Candia Flores	Egresado	Becario Pregrado (Categoria D)
Carla Maribel Miranda Oña	Bachiller	Becario Pregrado (Categoria D)
Grace Lizet Villanueva Calle	Licenciatura	Becario Pregrado (Categoria D)
Carolina Triguero Mamani	Egresado	Becario Pregrado (Categoria D)
Gloria del Carmen Rodrigo Lira	Doctorado Ph.D.	Co-Cordinador (Categoria D)
Giovanna Rocio Almanza Vega	Doctorado Ph.D.	Coordinador (Categoria D)
Wendy Alizon Soria Sotillo	Doctorado Ph.D.	Doctorando (Categoria D)
Maribel Lozano Palacios	Licenciatura	Doctorando (Categoria D)
Ruth Nina Huanca	Licenciatura	Investigador (Categoria D)
Teresa Maya Pacheco Machicado	Licenciatura	Investigador (Categoria D)
Juan Carlos Peñaranda Orosco	Licenciatura	Investigador (Categoria D)
Gilberto Chui Tinco	Licenciatura	Investigador (Categoria D)
Santiago Tarqui Tarqui	Licenciatura	Investigador (Categoria D)
Yonny Rene Flores Segura	Doctorado Ph.D.	Investigador (Categoria D)
Lily Salcedo Ortiz	Maestria	Investigador (Categoria D)
Santiago Tarqui Tarqui	Licenciatura	Investigador (Categoria D)
Marcos Heriberto Quiroz Mendoza	Licenciatura	Maestrante (Categoria D)
Angela Jhamilka San Martin Ortiz	Licenciatura	Maestrante (Categoria D)
Silvia Eugenia Ramos Paredes	Licenciatura	Maestrante (Categoria D)
Nancy Alejandra Navia Coarite	Licenciatura	Maestrante (Categoria D)
Patricia Yaquelin Suxo Tutila	Licenciatura	Maestrante (Categoria D)

- Colaboradores del proyecto

Nombre	Grado Académico	Cargo	Cédula de identidad
Franz Felipe Apaza Topoco	Bachiller	Chofer (Categoria D)
Ruben Choque Condori rbn.choque@hotmail.com		Chofer (Categoria D)
Hermenegildo Fernandez Callisaya	Bachiller	Chofer (Categoria D)
Juan Carlos Santelices Gomez santelicesgomez@gmail.com	Maestria	Coordinador de postgrado (Categoria D)
Stina Oredsson		Supervisor ()
Giovanna Rocio Almanza Vega giovyalmanza@gmail.com	Doctorado Ph.D.	Supervisor ()

Unidades Participantes

Unidad Proponente Instituto de Investigaciones Químicas

Unidad Contraparte

+ Unidades Co-Ejecutoras

Nombre de la Unidad	Responsable de la Unidad

Lineas de Investigación